| Monoclonal Anti-CD4 Antibody MT310 Binds HIV-1 gp120 Binding Site on CD4 |
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| 作者姓名： | 秦莉 朱梅 陈应华 |
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| 作者单位： | QIN Li，ZHU Mei，Gert Riethmuller ，Peter Rieber ，CHEN Yinghua ** Laboratory of Immunology，Research Center for Medical Science，Department of Biological Sciences and Biotechnology，Tsinghua University，Beijing 100084，China; Institute |
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| 基金项目： | Munich University in Germany and theNational Key Basic Research Specific Funds of China
(No.G19990 75 6 0 7) |
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| 摘 要： | IntroductionHuman immunodeficiency virus type1 ( HIV- 1 ) ,after binding by the envelope protein gp1 2 0 to itscellular receptor CD4,enters susceptible cellsthrough p H- independent fusion1,2 ] . The sitewhich HIV- 1 gp1 2 0 binds is located in the firstdomain on the CD4molecule3 5] .The anti- CD4m Ab Leu3a recognizes the gp1 2 0 binding site onCD46] and the anti- CD4m Ab MT31 0 stronglyinhibits HIV- 1 infection of CD4+ T cells,while theanti- CD4 m Ab MT1 5 1 weakly inhibitsinf…
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Monoclonal Anti-CD4 Antibody MT310 Binds HIV-1 gp120 Binding Site on CD4 |
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| Abstract: | |
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| Keywords: | anti idiotypic antibody epitope analysis anti CD4 antibody |
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