DNA methylation of fly genes and transposons |
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Authors: | M Mandrioli F Borsatti |
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Institution: | (1) Dipartimento di Biologia Animale, Università di Modena e Reggio Emilia, Via Campi 213/d, 41100 Modena, Italy |
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Abstract: | The use of anti-5-methylcytosine antibodies in affinity columns allowed the identification of methylated sequences in the
genome of Drosophila melanogaster adults. In view of the presence of transposable elements amongst the identified sequences, it has been suggested that DNA
methylation is involved in transposon control in the fly genome. On the contrary, a reanalysis of these data furnishes several
intriguing elements that could raise new questions about the role that DNA methylation plays in the fly genome. The aim of
the present paper is to discuss some features that emerge from the analysis of the identified methylated sequences.
Received 26 January 2006; received after revision 8 May 2006; accepted 2 June 2006 |
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Keywords: | DNA methylation gene expression transposon silencing development cytosine methylation function Drosophila melanogaster |
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