Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. |
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| Authors: | P J Peters J J Neefjes V Oorschot H L Ploegh H J Geuze |
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| Affiliation: | Laboratory of Cell Biology, Medical School, University of Utrecht, The Netherlands. |
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| Abstract: | Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis. |
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