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Furan fatty acid steryl esters from the marine spongeDictyonella incisa which show inflammatory activity
Authors:P Ciminiello  E Fattorusso  S Magno  A Mangoni  A Ialenti  M Di Rosa
Institution:(1) Dipartimento di Chimica delle Sostanze Naturali, Via D. Montesano 49, I-80131 Napoli, (Italy);(2) Dipartimento di Farmacologia Sperimentale, Via D. Montesano 49, I-80131 Napoli, (Italy)
Abstract:Summary Three new furan fatty acids, (9Z, 19Z)-3, 6-epoxyhexacosa-3,5,19-tetraenoic acid (1a), (8Z, 11Z, 14Z, 17Z)-3, 6-epoxyeicosa-3,5,8,11,14,17-hexaenoic acid (2a), and (8Z, 11Z, 14Z, 17E)-3, 6-epoxyeicosa-3,5,8,11,14,17-hexaenoic acid (3a), and a new polyunsaturated fatty acid (5Z, 8Z, 11Z, 14Z, 17E)-eicosa-5,8,11,14,17-pentaenoic acid (6a), present in the spongeDictyonella incisa as the respective steryl esters, have been isolated as methyl esters and their structures have been determined by spectral and chemical analysis. The furan fatty acid esters have shown a high inflammatory activity, which suggests their potential role as feeding deterrents.
Keywords:Dictyonella incisa  furan fatty acids  inflammatory activity  by histamine release
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