| 活性小分子的辐射效应 |
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| 引用本文： | 张尔贤,居军,刘晓林,郭善祥,刘锐.活性小分子的辐射效应[J].汕头大学学报(自然科学版),1986(1). |
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| 作者姓名： | 张尔贤 居军 刘晓林 郭善祥 刘锐 |
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| 作者单位： | 汕头大学生物学系、，甘肃生物所，汕头大学化工部三所，甘肃工业卫生所、，兰州大学 |
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| 摘 要： | 研究结果表明:1.600R 注 X 线照射后,小白鼠肝中谷胱甘肽(GSH)浓度下降50％(P<0.01)、脾中增高36％(P<0.05)、肾中下降15.9％(P<0.05).2.当小白鼠照射前注射 GSH 或半胱氨酸(CySH)能稳定 SH 基水平.3.采用放射免疫技术(RIA)测定小白鼠血清胰岛素浓度,照射后16小时降低22.5％.血糖浓度照射后18小时下降9％.血清环化腺苷单磷酸(cAMP)浓度照后16小时下降31％.4.不同剂量γ线照射后,鼠脑含磷化合物的合成受到强烈抑制.5.6000R γ线照射后兔的通透屏障受到明显影响.
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| 关 键 词： | 辐射 巯基 放射免疫分析 放射性同位素 环腺苷酸 通透屏障 |
Radiation Effect on the Small Active Molecules |
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| Zhang Erxian Ju Jun Liu Xiaolin Guo Shanxiang Liu Rui.Radiation Effect on the Small Active Molecules[J].Journal of Shantou University(Natural Science Edition),1986(1). |
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| Authors: | Zhang Erxian Ju Jun Liu Xiaolin Guo Shanxiang Liu Rui |
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| Institution: | Zhang Erxian Ju Jun Liu Xiaolin Guo Shanxiang Liu Rui |
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| Abstract: | The results obtained from the study are as follows:(1) After X-ray radiation at 600R,the concentration of GSH decreased by about 50% in the mice liver(P<0.01)and increased by 36% in the spleen(P<0.05) and decreased by 15.9% in the kidney (P<0.05).(2) The injection of GSH or CySH in mice before radiation can stabilize the level of SH.(3) The serum concentration of insulin in mice decreased by 22.5% after radia- tion for 16 hours,the concentration of blood sugar decreased by 9% after radiating for 18 hours and the cAMP concentration decreased by 31% after radiation for 16 hours.(4) The synthesis of phosphocompounds in the brains of mice was considerably inhibited after radiation.(5)The permea- bility barrier in rabbits was greatly influenced after X-ray radiation at 6000R. |
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| Keywords: | Radiation Sulfhydryl groups Insulin radioimmunoassay Radioactive isotope Cyclic adenosine monophosphate Permeability barrier |
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