Evolution of the serum resistance-associated SRA gene in African trypanosomes |
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Authors: | LAI DeHua WANG QiaoPing LI Zhi JULIUS Luke&scaron &LUN ZhaoRong |
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Institution: | (1) Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China;(2) Biology Centre, Institute of Parasitology, Czech Academy of Sciences; Faculty of Biology, University of South Bohemia, South Bohemia, 37005 České Budějovice (Budweis), Czech Republic |
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Abstract: | Serum resistance-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker
to distinguish this species from other African trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicates that they may have a common origin and are highly conserved. Since SRAbc coexists in the T. b. rhodesiense genome with SRA, we propose that SRAbc might be the ‘donor VSG’, which after duplication became inserted into the expression site by recombination. Under natural
selection, SRAbc could reform into SRA following mosaic formation.
Supported by National Natural Science Foundation of China (Grant Nos. 30570245, 30670275), Changjiang Scholars and Innovative
Research Team in University (Grant No. DPCKSCU/IRT0447), International Foundation for Science of Sweden (Grant No. B/4318-1),
Grant Agency of the Czech Republic (Grant No. Z60220518) and Education Foundation of the Czech Republic (Grant No. 2B06129) |
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Keywords: | SRA SRAbc evolution African trypanosomes |
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