| 基于生物信息学与分子结构的SARS冠状病毒主蛋白酶(SARS CoV Mpro)多肽类抑制剂研究 |
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| 引用本文： | 孙浩,李大鹏,谢军民,杜奇石.基于生物信息学与分子结构的SARS冠状病毒主蛋白酶(SARS CoV Mpro)多肽类抑制剂研究[J].天津师范大学学报(自然科学版),2006,26(2):10-12. |
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| 作者姓名： | 孙浩 李大鹏 谢军民 杜奇石 |
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| 作者单位： | 天津师范大学,生物信息与药物开发研究所,天津,300074 |
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| 摘 要： | 用冠状病毒基因解析软件系统ZCURVE_CoY2．0，从SARS冠状病毒（TOR2，NC_004718）的RNA基因序列出发，搜索出含有SARS冠状病毒主蛋白酶（SARS CoV M^pro）真实剪切位点的11个八肽，运用分子叠合和分子对接的方法，对11个八肽进行了分析，证明这11个八肽有相似的活性，而且11个八肽中，op4的活性最高．分析认为，op4有望成为抗SARS药物的理想前体．
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| 关 键 词： | 冠状病毒主蛋白酶 多肽 |
| 文章编号： | 1671-1114(2006)02-0010-03 |
| 修稿时间： | 2005年9月25日 |
Reaserch of Multipeptid Inhibitors for SARS Coronavirus Main Protease(SARS CoV Mpro) Driven by Informatics and Molecular Structure |
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| SUN Hao,LI Da-peng,XIE Jun-min,DU Qi-shi.Reaserch of Multipeptid Inhibitors for SARS Coronavirus Main Protease(SARS CoV Mpro) Driven by Informatics and Molecular Structure[J].Journal of Tianjin Normal University(Natural Science Edition),2006,26(2):10-12. |
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| Authors: | SUN Hao LI Da-peng XIE Jun-min DU Qi-shi |
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| Abstract: | In the analysis of SARS coronavirus genomes(TOR2,NC__004718),11 cleavage octapeptides were found by ZCURVE-CoV 2.0,a program developed Tianjin University.The 11 octapeptides were analyzed using molecule alignment and molecule docking.It was found that the activities of the 11 octapeptides were similar and op4 had the highest activity.The reasons of the high activity of the op4 were analysed.It indicated that op4 would probablely became the best candidates for anti-SARS drug. |
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| Keywords: | SARS |
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