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| 微波促进下3,4-二氢嘧啶-2-酮衍生物的有效合成及其抗菌活性 | |
| 引用本文： | 李小六,冯俊娜,王东跃,陈华,万素英,曹克强.微波促进下3,4-二氢嘧啶-2-酮衍生物的有效合成及其抗菌活性[J].河北大学学报(自然科学版),2009,29(5). |
| 作者姓名： | 李小六 冯俊娜 王东跃 陈华 万素英 曹克强 |
| 作者单位： | 1. 河北大学化学与环境科学学院,河北省化学生物学重点实验室,河北保定,071002 2. 河北农业大学理学院,河北保定,071001 3. 河北农业大学植物保护学院,河北保定,071001 |
| 基金项目： | 河北省自然科学基金资助项目 |
| 摘 要： | 利用微波促进的方法,通过Biginelli反应,以脂肪醛和杂环醛为原料、三氟醋酸(或冰醋酸)为催化剂,简便、高效地合成了一系列含脂肪烃基或杂环基的3,4-二氢嘧啶-2-酮衍生物,并首次对化合物抗植物病菌活性进行了初步测试. |
| 关 键 词： | 3 4-二氢嘧啶-2-酮 微波促进有机合成 Biginelli反应 |
Microwave Assisted Synthesis and Biological Study of 3,4-Dihydropyrimidin-2(1H)-ones |
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| LI Xiao-liu,FENG Jun-na,WANG Dong-yue,CHEN Hua,WAN Su-ying,CAO Ke-qiang.Microwave Assisted Synthesis and Biological Study of 3,4-Dihydropyrimidin-2(1H)-ones[J].Journal of Hebei University (Natural Science Edition),2009,29(5). | |
| Authors: | LI Xiao-liu FENG Jun-na WANG Dong-yue CHEN Hua WAN Su-ying CAO Ke-qiang |
| Institution: | 1.Key Laboratory of Cheimcal Biology of Hebei Province;College of Chemistry and Environmental Sciences;Hebei University;Baoding 071002;China;2.College of Science;Agricultural University of Hebei;Baoding 071001;3.College of Plant Protection;China |
| Abstract: | The microwave assisted synthesis of a series of 3,4-dihydropyrimidin-2(1H)-one derivatives were described with Biginelli condensation of aliphatic and heterocyclic aldehydes,ethyl acetacetate and urea in the presence of trifluoroacetic acid.The one-pot reaction had such advantages as short reaction time,simple procedure and high yields.The anti-bacterial activity of the compounds was also examined. |
| Keywords: | 3 4-Dihydropyrimidin-2(1H)-ones microwave-assisted organic synthesis Biginelli reaction |
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