维医异常黑胆质证与肿瘤患者血浆脂肪酸含量变化的相关性

 从脂肪酸代谢水平阐释“异病同证”、“同证同理”等维医基础理论的科学性以及探讨不同肿瘤异常黑胆质证患者体内脂肪酸代谢变化。肿瘤病异常黑胆质证患者122 例，其中包括食管癌患者25例、肠癌患者20 例、肺癌患者33 例、乳腺癌患者20 例和胃癌患者24 例；另选35例健康志愿者为对照组；采用气相色谱法（gas chromatography，GC）对患者血浆进行10 种脂肪酸的定量检测；对患者与健康对照组之间的不同脂肪酸含量的差异性采用SPSS 16.0 软件进行独立样本的t 检验。结果显示，肉豆蔻酸在食管癌、肠癌、肺癌、乳腺癌和胃癌异常黑胆质证患者体内的含量均明显升高，这是本研究中所有肿瘤患者共同的特点；食管癌异常黒胆质证患者体内棕油酸、油酸、花生酸和DHA 含量明显升高，而亚油酸、花生四烯酸含量明显降低；肠癌异常黑胆质证患者体内棕榈酸和油酸含量明显升高；肺癌异常黑胆质证患者体内棕油酸、棕榈酸、油酸和花生酸含量明显升高，而亚油酸含量明显降低；乳腺癌异常黑胆质证患者体内棕油酸、棕榈酸、油酸、花生酸和EPA 含量明显升高，而硬脂酸和花生四烯酸含量明显降低；胃癌异常黑胆质证患者体内的棕油酸和DHA 含量明显升高，而亚油酸、EPA 和花生四烯酸含量明显降低。由此得出，不同病种肿瘤异常黑胆质证患者血浆脂肪酸代谢特点有共性，也有明显的差异性。

Correlation Analysis of Plasma Fatty Acid Levels in Patients with Tumor and Abnormal Savda in Uyghur Medicine

To investigate the plasma fatty acid metabolism of different cancer patients with abnormal Savda in Uyghur medicine and analyze its common features, the plasma fatty acid concentration was tested by the gas chromatography (GC) from 122 cases of cancer patients with abnormal Savda including 25 cases of esophageal cancer, 20 cases of colorectal cancer, 33 cases of lung cancer, 20 cases of breast cancer and 24 cases of gastric cancer, and 35 healthy volunteers as a control group. The spectral profiles were subjected to a t-test for statistical significance. The results show that compared to the healthy group, the patients of esophageal cancer, colorectal cancer, lung cancer, breast cancer and gastric cancer with abnormal Savda suffer a high concentration of myristic acid; the patients of esophageal cancer, lung cancer, breast cancer and gastric cancer with abnormal Savda suffer a high concentration of palm acid; the patients of colorectal cancer, lung cancer and breast cancer with abnormal Savda suffer a high concentration of palmitic acid; the patients of esophageal cancer, lung cancer and gastric cancer with abnormal Savda suffer a low concentration of linoleic acid; the patients of esophageal cancer, colorectal cancer, lung cancer and breast cancer with abnormal Savda suffer a high concentration of oleic acid; the patients of breast cancer patients with abnormal Savda suffer a low concentration of stearic acid; the patients of esophageal cancer and gastric cancer with abnormal Savda suffer a low concentration of arachidonic acid; the patients of breast cancer patients with abnormal Savda suffer a high concentration of EPA, but the patients of gastric cancer with abnormal Savda suffer a low concentration of EPA; the patients of esophageal cancer, lung cancer and breast cancer with abnormal Savda suffer a high concentration of arachidic acid; the patients of esophageal cancer and gastric cancer with abnormal Savda suffer a high concentration of DHA. It is concluded that these findings suggest that different tumor patients with abnormal Savda see some common characteristics, and also significant differences.