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| 马兜铃酸-A衍生物合成及其生物活性研究 | |
| 引用本文： | 朴红善,李京淑,金玉子,韩春姬,李莲姬,史昆波.马兜铃酸-A衍生物合成及其生物活性研究[J].内蒙古大学学报(自然科学版),2010,41(1). |
| 作者姓名： | 朴红善 李京淑 金玉子 韩春姬 李莲姬 史昆波 |
| 作者单位： | 1. 大连工业大学化工与材料学院,辽宁,大连,116034 2. 延边大学师范学院 3. 延边大学医学部,吉林,延吉,133000 |
| 基金项目： | 国家自然科学基金资助项目(批准号:29862004) |
| 摘 要： | 从关木通中分离提取马兜铃酸-A,合成了两种新的马兜铃酸-A衍生物:1-O-马兜铃酰基-2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖(Ⅱ)和1-O-马兜铃酰基-2,3,4,6-四-O-乙酰基-β-D-吡喃半乳糖(Ⅲ).元素分析、核磁共振、红外光谱表征了它们的结构,并对马兜铃酸-A及其衍生物(马兜铃内酰胺、马兜铃酸葡萄糖基酯、马兜铃次酸)进行了对S180肿瘤细胞作用的研究. |
| 关 键 词： | 马兜铃酸-A 马兜铃酸-A衍生物 葡萄糖 半乳糖 生物活性 |
Study on the Synthesis and Bioactivity of Aristolochic acid A Derivatives |
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| PIAO Hong-shan,LI Jing-shu,JIN Yu-zi,HAN Chun-ji,LI Lian-ji,SHI Kun-bo.Study on the Synthesis and Bioactivity of Aristolochic acid A Derivatives[J].Acta Scientiarum Naturalium Universitatis Neimongol,2010,41(1). | |
| Authors: | PIAO Hong-shan LI Jing-shu JIN Yu-zi HAN Chun-ji LI Lian-ji SHI Kun-bo |
| Institution: | 1.School of Chemistry Engineering and Material/a>;Dalian Polytechnic University/a>;Dalian 116034/a>;China/a>;2.Normal College/a>;Yanbian University/a>;3.Health Science Center/a>;Yanji 133000/a>;China |
| Abstract: | Two new Aristolochic acid A derivatives,1-O-aristolochyl-2,3,4,6-tetra-O-acetayl-β- D-glucopyranose (Ⅱ) and 1-O-aristolochyl-2,3,4,6-tetra-O-acetayl-β-D-galactopyranose (Ⅲ) were synthesized from Aristolochic acid A,which was extracted from Guan mutong.Their structure were confirmed by IR,1H-NMR and element analysis.The bioactivity of Aristolochic A and its derivatives (acidaristololactam,aristolochic acid glucosyl ester,Aristolic acid) on S180 tumor cell were studied. |
| Keywords: | aristolochic acid A aristolochic acid A derivatives glucose galactose bioactivity |
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