| 改进羧化试剂合成硝基苯乙酸 |
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| 引用本文： | 李晓如,林富钦.改进羧化试剂合成硝基苯乙酸[J].湘潭大学自然科学学报,1991,13(3):66-69. |
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| 作者姓名： | 李晓如 林富钦 |
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| 作者单位： | 湖南医专有机教研室
(李晓如)，广州师范学院化学系(林富钦) |
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| 摘 要： | 0 前言硝基苯乙酸是重要的医药和有机合成中间体,其经典合成方法常由于原料难得或使用毒性大的腈化物,给工业生产带来困难。G.Bottaccio等报道了对硝基甲苯在酚钠的存在下能和CO_2发生羧基化反应,得对硝基苯乙酸.所用溶剂为昂贵的六甲基
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| 关 键 词： | 硝基甲苯 硝基苯乙酸 合成 碳酸盐 苯酚钠 |
IMPROVEMENT ON CARBOXYLATION AGENT TO SYNTHESIZE NITROPHENYLACETIC ACIDS |
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| Li Xiaoru.IMPROVEMENT ON CARBOXYLATION AGENT TO SYNTHESIZE NITROPHENYLACETIC ACIDS[J].Natural Science Journal of Xiangtan University,1991,13(3):66-69. |
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| Authors: | Li Xiaoru |
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| Abstract: | An improvement on carboxylation agent to synthesizenitrophenylacetic acids has been worked out, in which sodium carbonates(or potassium carbonate) is used as a part of carboxylation agent. whenmole ratio-sodium phenolate: nitrotoluene(o-or p-) :sodium sarbonate(or potassium carbonate) attains 2:1:0.5, o-nitrophenylacetic acid yieldsin 82%, and p-nitrophenylacetic acid in 90%, if adding a little of tetra-butyl ammonium bromide at the same time. |
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| Keywords: | nitrotoluene nitrophenylacetic acid synthesize carbonate sodium phenolate |
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