| 电喷雾萃取电离质谱技术及其应用进展 |
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| 引用本文： | 贾滨,张兴磊,丁健桦,杨水平,陈焕文.电喷雾萃取电离质谱技术及其应用进展[J].科学通报,2012(20):1918-1927. |
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| 作者姓名： | 贾滨 张兴磊 丁健桦 杨水平 陈焕文 |
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| 作者单位： | 东华理工大学,江西省质谱科学与仪器重点实验室 |
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| 基金项目： | 国家自然科学基金(21175019);国家重大科学仪器设备开发专项(2011YQ140150)资助 |
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| 摘 要： | 电喷雾萃取电离(EESI)技术是近年发展起来的一种可以在无需样品预处理的条件下对复杂基体样品进行直接质谱分析的新兴离子化技术.该技术能对液体、气溶胶、固体表面、黏性样品等不同形态样品进行分析.本文介绍了EESI技术的工作原理,系统阐述了EESI-MS技术在实际样品分析中的实现方式和技术特点,对EESI-MS现有的应用进行了简要的归纳和评述,展望了EESI技术在食品医药安全、公共安全、化学反应机理研究、代谢组学、蛋白质分析、临床诊断、环境监测等领域中的应用前景.
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| 关 键 词： | 质谱 直接离子化技术 电喷雾萃取电离 |
Principle and applications of extractive electrospray ionization mass spectrometry |
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| JIA Bin,ZHANG XingLei,DING JianHua,YANG ShuiPing & CHEN HuanWen.Principle and applications of extractive electrospray ionization mass spectrometry[J].Chinese Science Bulletin,2012(20):1918-1927. |
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| Authors: | JIA Bin ZHANG XingLei DING JianHua YANG ShuiPing & CHEN HuanWen |
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| Institution: | Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,College of Chemistry,Biology and Material Science,East China Institute of Technology,Nanchang 330013,China |
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| Abstract: | Extractive electrospray ionization mass spectrometry(EESI-MS),an ambient ionization technique for direct analysis of complex samples without sample pretreatment,is undergoing rapid development,and has been wildly used in the analysis of liquids,aerosols,solid surfaces and viscous liquids.In this paper,the mechanism of EESI is introduced,the specific implementations and characteristics of EESI-MS in the analysis of real samples are described,and the new applications of EESI-MS are discussed.Moreover,the usability of EESI-MS in the field of food and drug safety;public security;chemical reaction mechanisms;metabolomics;protein analysis;clinical diagnostic and environmental monitoring are exemplified using cases demonstrated in the literature. |
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| Keywords: | mass spectrometry ambient ionization for direct analysis extractive electrospray ionization |
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