Regulation of lymphokine production in peripheral blood mononuclear cell cultures

Summary An increase in the production of macrophage migration inhibitory factor, chemotactic factor for neutrophils, and skin reactive factor, was observed in lymphocyte cultures if the cells were allowed to age in culture for 24 h. The increased lymphokine production was reduced by adding concanavalin A-stimulated and mitomycin C-treated suppressor cells. It is suggested that the lymphokine production could be regulated by suppressive mononuclear cells.This work was supported by the Scientific Research Council, Ministry of Health, Hungary (Code No. 421 0304011/S).