Brain factor from Galleria mellonella (Lepidoptera) stimulating silk gland activity. |
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Authors: | J Michalik E Szolajska Z Lassota |
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Institution: | Department of Comparative Biochemistry, Polish Academy of Sciences, Warsaw. |
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Abstract: | Brain extracts from day 1-4 last instar larvae of Galleria mellonella (Lepidoptera) stimulate RNA synthesis in cultured silk glands from day 3 last instar larvae. When the fibroin-synthesizing posterior parts of silk glands were incubated for 3 h in vitro in the presence of brain extract (0.1 brain equivalent), 3H]-uridine incorporation into RNA was stimulated more than twofold. The stimulating effect of brain extract showed a dose response relationship. It is suggested that the heat-resistant and protease-sensitive brain factor is a peptide. |
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