Dämpfung des Kältezitterns durch Pentobarbital und Pethidin bei Ratten |
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| Authors: | H Schäfer |
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| Institution: | (1) Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg, Deutschland |
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| Abstract: | Summary In rats, shivering was induced by cooling. Shivering started at 36.6°C in unanaesthetized rats and at 36.0°C in animals with light pentobarbital anaesthesia (5 mg/kg i.V.). Pethidine (2 mg/kg) lowered the onset of shivering in unanaesthetized rats to 35.3 °C and in anaesthetized animals to 33.0°C. The results suggest that the effect of pethidine upon shivering is potentiated by pentobarbital. |
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