| CCL25/CCR9与骨髓祖细胞胸腺归巢 |
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| 引用本文： | 张琳,郝选明,邓树勋,肖鹏. CCL25/CCR9与骨髓祖细胞胸腺归巢[J]. 河南师范大学学报(自然科学版), 2011, 39(1): 142-145 |
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| 作者姓名： | 张琳 郝选明 邓树勋 肖鹏 |
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| 作者单位： | 1. 华南师范大学生命科学学院,广州,510631
2. 华南师范大学体育科学学院,广州,510631 |
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| 摘 要： | 在骨髓中多种祖细胞有T细胞系潜能,但骨髓祖细胞胸腺归巢具有选择性.骨髓祖细胞胸腺归巢是多级粘附分子和趋化因子的级联过程,趋化因子CCL25及其受体CCR9在这一过程中发挥了重要作用.综述了CCL25/CCR9的结构特征及其对骨髓祖细胞胸腺归巢的作用和调节机制.
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| 关 键 词： | 骨髓祖细胞 胸腺归巢 CC 趋化因子配体 25 CC 趋化因子受体 9 fms 样酪氨酸激酶受体-3 |
CCL25/ CCR9 and Homing of Bone Marrow-derived Progenitors to the Thymus |
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| ZHANG Lin,HAO Xuan-ming,DENG Shu-xun,XIAO Peng. CCL25/ CCR9 and Homing of Bone Marrow-derived Progenitors to the Thymus[J]. Journal of Henan Normal University(Natural Science), 2011, 39(1): 142-145 |
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| Authors: | ZHANG Lin HAO Xuan-ming DENG Shu-xun XIAO Peng |
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| Affiliation: | a(a.College of Life Sciences;b.School of Physical Education & Sports Science,South China Normal University,Guangzhou 510631,China) |
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| Abstract: | Although multiple progenitors within the bone marrow have T lineage potential,homing of bone marrow-derived progenitors to the thymus is selective.A multistep adhesion cascades for lymphoid progenitor cell homing to the thymus.The role of the CCL25/CCR9 pathway in lymphoid progenitor homing is important.The structure and the role of CCL25/CCR9pathway in lymphoid progenitor homing as well as the mechanism are viewed. |
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| Keywords: | bone marrow-derived progenitors homing to the thymus CC chemokine ligand 25(CCL25) CC chemokine receptor 9(CCR9), fms-like tyrosine kinase receptor-3(Flt3) |
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