| H~3-藻酸双酯钠的药物动力学研究 |
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| 引用本文： | 刘忠敏,姜国华,仪明光,车璟.H~3-藻酸双酯钠的药物动力学研究[J].北京师范大学学报(自然科学版),1991(2). |
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| 作者姓名： | 刘忠敏 姜国华 仪明光 车璟 |
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| 作者单位： | 北京师范大学分析测试中心，北京师范大学分析测试中心，中国原子能研究院，青岛第三制药厂 北京 |
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| 摘 要： | 研究了不同剂量~3H-藻酸双酯钠(PSS)在小鼠及大鼠体内的吸收、分布,排泄及药物代谢动力学参数.无论口服或静注小鼠组织分布较广,12h 以肝、肾最高,脑,脂肪、骨骼较低,大脑、小脑、脑干放射性分布未见明显差异.静注72h 自小鼠尿排泄60%,粪排泄20%.大鼠口服24h 由胆汁排泄15.3%.小鼠及人血血浆蛋白结合率24h 为98%.PSS 0.8%CMC 混悬液口服的绝对生物利用度为75.6%,具有吸收好,分布广,排泄快等特点.
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| 关 键 词： | 藻酸双酯钠 药物动力学 体内过程 生物利用度 |
A STUDY ON THE PHARMACOKINETICS OF ~3H-POLY SACCHARIDE SUIPHATE(PSS) IN MICE AND RATS |
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| Liu Zhongmin Jiang Guohua.A STUDY ON THE PHARMACOKINETICS OF ~3H-POLY SACCHARIDE SUIPHATE(PSS) IN MICE AND RATS[J].Journal of Beijing Normal University(Natural Science),1991(2). |
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| Authors: | Liu Zhongmin Jiang Guohua |
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| Abstract: | A study on absorption,distribution excertion and pharmaco- kinetic parameters of ~3H-poly saccharide suiphate(PSS) in mice and rats is reported.The blood concentration-time obtained after introvenous injection of ~3H-PSS to mice is shown to fit a tree-comparment open model,after oral is shown to fit a two-compartment open model.The drug concentration is found to be highest in liver and kidney,moderate in lung,spleen,intestine, stomach,heart,muscle and lower in bone,brain and fat.Within 72h follow- ing iv the total radioactivity excreted in urine and feces is 59.52% and 20.23% of dose,after oral 12h excred in bile is 15.3% in rats.The bioava- liability is 75.6%,the drug-plasms protin binding of ~3H-PSS is found to be 97.6% in human and 98.1% in mice. |
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| Keywords: | poly saccharide suiphate pharmacokinetics drug disposition bioavailability |
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