Leonurine,an improved synthesis |
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| Authors: | K F Cheng C S Yip H W Yeung Y C Kong |
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| Institution: | (1) Chemistry Department, University of Hong Kong, (Hong Kong);(2) Biochemistry Department, Chinese University of Hong Kong, (Hong Kong) |
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| Abstract: | Summary Leonurine (1) is the uterotonic principle ofLeonurus artemisia. We have developed a simple, high-yield synthetic procedure of1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 1 1 HMPT-ether as solvent. The synthetic leonurine showed uterotonic activity in vivo and in vitro.Acknowledgment. This work was partly supported by World Health Organization, Geneva, Switzerland. |
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