应用天然蛋白质片段构建蛋白质分子机器的初步尝试

根据对蛋白质分子结构可塑性和结构重组的理解,本文介绍了如何以来源于不同蛋白质的功能片段和人为设计的多肽片段为部件,组装出一组多结构域融合蛋白。在体外和体内实验中,这些多结构域融合蛋白表现出了我们所期待的特定功能。它们将有可能发展成为一系列新型抗菌和抗肿瘤药物。与现用药物相比,它们的效力更高,靶向性更强,更为安全。它们有可能会很快地代替现用药物,为人类创造更好的福祉。而以这些雏型为基础,则有可能构建出具有更理想功能的蛋白质分子机器。

Using Selected Protein Fragments to Comprise Multidomain Protein Machine, a Preliminary Exploration

With understanding about the plasticity and recombination of protein structures,a few multidomain fusion proteins have been comprised with functional fragments of different proteins and artificial derivative peptides.In in vitro and in vivo experiments,fused proteins behaved demanding functions as we expected.They could be developed as a series of innovative antibiotic and anti-tumor drugs.By comparison with current drugs,they may have higher efficiency,better targeting ability and more safety as more ideal...