| 六氢吡啶催化合成乙酰水杨酸的研究 |
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| 引用本文： | 徐翠莲,陈伟,宛新生,苏惠,党玉丽. 六氢吡啶催化合成乙酰水杨酸的研究[J]. 河南科学, 2008, 26(12) |
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| 作者姓名： | 徐翠莲 陈伟 宛新生 苏惠 党玉丽 |
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| 作者单位： | 河南农业大学,理学院,郑州,450002;河南农业大学,理学院,郑州,450002;河南农业大学,理学院,郑州,450002;河南农业大学,理学院,郑州,450002;河南农业大学,理学院,郑州,450002 |
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| 摘 要： | 以水杨酸和乙酸酐为原料,以六氢吡啶为催化剂,合成了乙酰水杨酸,对反应条件进行了优化.结果表明,当水杨酸与乙酸酐物质的量比为1∶3,六氢吡啶为水杨酸质量的17%时,在83℃反应55min,乙酰水杨酸的产率可达88.4%.
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| 关 键 词： | 六氢吡啶 乙酰水杨酸 合成 |
Synthesis of Aspirin with Piperidine as Catalyst |
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| Xu Cuilian,Chen Wei,Wan Xinsheng,Su Hui,Dang Yuli. Synthesis of Aspirin with Piperidine as Catalyst[J]. Henan Science, 2008, 26(12) |
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| Authors: | Xu Cuilian Chen Wei Wan Xinsheng Su Hui Dang Yuli |
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| Affiliation: | Xu Cuilian,Chen Wei,Wan Xinsheng,Su Hui,Dang Yuli(Science of College,Henan Agricultural University,Zhengzhou 450002,China) |
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| Abstract: | Acetyl salicylic acid was synthesized from salicylic acid and acetic anhydride catalysed by piperidine. The expected compound could be obtained in 88.4 % yield after heating of the reaction mixtures(the ratio of salicylic acid and acetic anhydride 1∶3.0,the mole ratio of piperidine 17 %,83 ℃ reaction for 30 min) . It showed that acetyl salicylic acid was synthesized in high yield with the catalysis of piperidine. |
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| Keywords: | piperidine acetyl salicylic acid synthesize |
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