Plasma and hepatic antioxidant control and vitamin A nutritional status |
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Authors: | I Subirade Y Fernandez B Périquet S Mitjavila F Anglade A Périquet |
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Institution: | (1) Laboratoire des Xénobiotiques, I.N.R.A., 180 chemin de Tournefeuille, B.P. 3, 31931 Toulouse Cédex, (France);(2) Service du Professeur Thouvenot, Biochimie, Secteur Chromatographie, Hôpital Purpan, 31059 Toulouse Cédex, (France) |
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Abstract: | Twenty-seven rats were divided into three groups and fed on diets containing 0.3, 6 or 60 RE (retinol equivalent) retinyl palmitate/g food. After 7 weeks, hepatic vitamin A uptake was found to be more efficient in vitamin A-deficient rats than in rats given adequate vitamin A. We showed that during the metabolic adaptation of the animals to the level of vitamin A in the diet, extensive modifications occur in the antioxidant defences of the organism. In parallel with the increase in the level of vitamin A, the decrease in the level of -tocopherol in the plasma can bring about a greater susceptibility of the lipoproteins to oxidative stress. Similarly, the decrease in the hepatic -tocopherol level and in glutathione peroxidase activity leads to the weakening of the liver's antioxidant defences. |
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Keywords: | Vitamin A diet rats plasma liver scavengers antioxidant enzymes |
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