Effect of Salvianolic Acid B on Mitochondrial Function of CerebralIschemia in Mice |
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| Authors: | JIANG Yufeng LUO Xuechun WANG Ximei FANG Lei HUANG Qifu |
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| Affiliation: | aDepartment of Pathology, Beijing University of Chinese Medicine, Beijing 100029, China;bDepartment of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;cState Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China |
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| Abstract: | The effects of salvianolic acid B (SalB) on the mitochondrial membrane potential (MMP), calcium, and apoptosis of neurons with cerebral ischemia in mice were investigated using an acute cerebral ischemia model established by ligating the bilateral common carotid arteries in mice. The MMP, the intracellular calcium concentration, and the apoptosis rate of cortical neurons were measured at 6 min, 12 min, 18 min, 24 min, and 30 min after cerebral ischemia by a flow cytometer. The experiments show that SalB increases the MMP and reduces the intracellular calcium and the apoptosis rate at different stages of the cerebral ischemia in mice. The results show that the protective mechanism of SalB on cerebral ischemia enhances the MMP and maintains intracellular calcium homeostasis. |
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| Keywords: | brain ischemia mitochondrial membrane potential calcium apoptosis salvianolic acid B (SalB) NIH mice |
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