| DL-正缬氨酸合成工艺的研究和改进 |
| |
| 引用本文： | 钏永明,李宏利,蒋琳,季四平,袁明龙.DL-正缬氨酸合成工艺的研究和改进[J].云南民族大学学报(自然科学版),2014,23(6):408-410. |
| |
| 作者姓名： | 钏永明 李宏利 蒋琳 季四平 袁明龙 |
| |
| 作者单位： | 云南民族大学云南省生物高分子功能材料工程技术研究中心,云南昆明,650500 |
| |
| 基金项目： | 云南省教育厅科学研究基金 |
| |
| 摘 要： | 报道了一种改进的合成DL-正缬氨酸的方法,以正戊酸为起始原料,通过酰氯化、羰基α-溴化,酰氯水解后先制得α-溴代的正戊酸,再通过氨解反应制得DL-正缬氨酸.经4步反应得到DL-正缬氨酸,总收率为67%.与现有方法相比较,反应条件温和,反应活性高,操作简便,试剂廉价易得,产物收率高.
|
| 关 键 词： | DL-正缬氨酸 正戊酸 溴化 氨解 |
Research and improvement on the synthesis process of DL-valine |
| |
| CHUAN Yong-ming,LI Hong-li,JIANG Lin,JI Si-ping,YUAN Ming-long.Research and improvement on the synthesis process of DL-valine[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2014,23(6):408-410. |
| |
| Authors: | CHUAN Yong-ming LI Hong-li JIANG Lin JI Si-ping YUAN Ming-long |
| |
| Institution: | CHUAN Yong-ming;LI Hong-li;JIANG Lin;JI Si-ping;YUAN Ming-long;Engineering Research Center of Biopolymer Functional Materials of Yunnan,Yunnan Minzu University; |
| |
| Abstract: | Aiming at the synthesis of DL-norvaline,an improved synthetic process of DL-novaline from n-valeric acid via the chloroformylation,bromination of carbonyl α-position,hydrolyzed and ammonolysis reactions was reported,with the total yield being 67 %. Compared with reported methods,the improved process had some advantages such as mild reaction conditions,high reactivity,easy operation,readily available reagents and high product yield. |
| |
| Keywords: | DL-valine n-valeric acid bromination ammonolysis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
