| 经Cu(I)催化合成2-苯基噁唑[3, 2-a]苯并咪唑 |
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| 引用本文： | 赵霞,陈定奔.经Cu(I)催化合成2-苯基噁唑[3, 2-a]苯并咪唑[J].科学技术与工程,2012,12(3). |
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| 作者姓名： | 赵霞 陈定奔 |
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| 作者单位： | 台州学院,台州学院 |
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| 基金项目： | 浙江省自然科学基金项目, 浙江省大学生科技创新活动计划（新苗人才计划）项目 |
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| 摘 要： | 2-巯基苯并咪唑经溴化反应得到2-溴苯并咪唑，然后与ω-溴代苯乙酮发生亲核取代反应进一步得到中间体，最后通过Cu(I)催化偶联关环得到产物2-苯基噁唑3, 2-a]苯并咪唑。化合物的结构通过1HNMR,13CNMR得到了证实。在本文中，我们也初步考察了溶剂、碱、配体对Cu(I)催化偶联关环得到产物2-苯基噁唑3, 2-a]苯并咪唑反应的影响。
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| 关 键 词： | 2-苯基噁唑[3 2-a]苯并咪唑 Cu(I)催化 偶联反应 合成 |
| 收稿时间： | 2011/10/27 0:00:00 |
| 修稿时间： | 2011/11/20 0:00:00 |
Synthesis of 2-Phenyloxazolo[3,2-a]benzimidazole by Cu(I)-Catalyzed Cyclization. |
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| zhaoxia and chendingben.Synthesis of 2-Phenyloxazolo[3,2-a]benzimidazole by Cu(I)-Catalyzed Cyclization.[J].Science Technology and Engineering,2012,12(3). |
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| Authors: | zhaoxia and chendingben |
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| Institution: | Taizhou University |
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| Abstract: | The product, 2-phenyloxazolo3,2-a]benzimidazole was synthesized by three steps. Firstly, 2-bromo-1H-benzod]imidazole was obtained after1H-benzod]imidazole -2-thiol was brominated. Then 2-bromo-1H-benzod]imidazole reacted with 2-bromo-1-phenyl-ethanone, the intermediat was gotten. At last, 2-Phenyloxazolo3,2-a]benzimidazole was synthesized by copper-catalyzed cyclization. We investigated the influence of the solvents, bases, ligands on the Coupling cyclization of 2-Phenyloxazolo3,2-a]benzimidazole. |
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| Keywords: | 2-Phenyloxazolo[3 2-a]benzimidazole Coupling reaction Copper(I)-catalyzed Synthesis |
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