Goniothalamicin and annonacin: Bioactive acetogenins fromGoniothalamus giganteus (Annonaceae) |
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| Authors: | A. Alkofahi J. K. Rupprecht D. L. Smith Ch. -J. Chang J. L. McLaughlin |
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| Affiliation: | (1) Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907 West Lafayette, Indiana, USA |
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| Abstract: | Summary Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid  -lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity ofII was confirmed, andII is now also found to be weakly active against 3PS murine leukemia. |
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| Keywords: | Goniothalamicin annonacin acetogenins Goniothalamus giganteus Annonaceae brine shrimp insecticidal cytotoxic antileukemic activity |
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