Characterization of the 5-HT1A receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior |
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Authors: | Markus Thamm Sabine Balfanz Ricarda Scheiner Arnd Baumann Wolfgang Blenau |
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Institution: | 1. Institute of Biochemistry and Biology, Animal Physiology, University of Potsdam, Karl-Liebknecht-Str. 24-25, Haus 26, 14476, Potsdam, Germany 2. Institute of Structural Biology and Biophysics 1, Forschungszentrum Jülich, 52425, Jülich, Germany
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Abstract: | Serotonin plays a key role in modulating various physiological and behavioral processes in both protostomes and deuterostomes.
The vast majority of serotonin receptors belong to the superfamily of G-protein-coupled receptors. We report the cloning of
a cDNA from the honeybee (Am5-ht1A) sharing high similarity with members of the 5-HT1 receptor class. Activation of Am5-HT1A by serotonin inhibited the production of cAMP in a dose-dependent manner (EC50 = 16.9 nM). Am5-HT1A was highly expressed in brain regions known to be involved in visual information processing. Using in vivo pharmacology,
we could demonstrate that Am5-HT1A receptor ligands had a strong impact on the phototactic behavior of individual bees. The data presented here mark the first
comprehensive study—from gene to behavior—of a 5-HT1A receptor in the honeybee, paving the way for the eventual elucidation of additional roles of this receptor subtype in the
physiology and behavior of this social insect. |
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