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| 紫外-可见光度法测定茶碱缓释片中茶碱的研究 | |
| 引用本文： | 卫世乾,贠嫣茹,张立科.紫外-可见光度法测定茶碱缓释片中茶碱的研究[J].江西师范大学学报(自然科学版),2012,36(2):205-208. |
| 作者姓名： | 卫世乾 贠嫣茹 张立科 |
| 作者单位： | 1. 许昌学院学报编辑部,河南许昌,461000 2. 许昌职业技术学院成人教育部,河南许昌,461000 3. 许昌学院化学化工学院,河南许昌,461000 |
| 基金项目： | 河南省教育厅自然科学基金(2010B150031);许昌学院科研基金(2011B022)资助项目 |
| 摘 要： | 在H2BO3-Na2B4O7缓冲溶液中,甲酚红同茶碱会发生诱导荷移反应,使其吸收光谱发生变化.以十二烷基磺酸钠作增敏剂,常温下显色20 min,茶碱与甲酚红形成2︰1型络合物,其λmax=570 nm,摩尔吸光系数κ=5.56×105L/(mol.cm),茶碱浓度在0.10~8.00μg/mL范围内符合比尔定律,线性回归方程为A=0.064 36C 0.058 50,相关系数R=0.999 1,根据信噪比确定的检测限(S/N=3,n=3)为0.172μg/mL.该方法简单易行,准确度、灵敏度高,适用于快速、大批量地分析茶碱缓释片中的茶碱. |
| 关 键 词： | 茶碱缓释片 茶碱 甲酚红 分光光度法 |
The Determination of Theophylline in Sustained-Release Tablet with the UV-Vis Spectrophotometry |
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| WEI Shi-qian , YUN Yan-ru , ZHANG Li-ke.The Determination of Theophylline in Sustained-Release Tablet with the UV-Vis Spectrophotometry[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2012,36(2):205-208. | |
| Authors: | WEI Shi-qian YUN Yan-ru ZHANG Li-ke |
| Institution: | 1.Journal Editorial Section,Xuchang University,Xuchang Henan 461000,China;2.Adult Education Department,Xuchang Vocational and Technical College,Xuchang Henan 461000,China;3.College of Chmistry and Chmical Engneering,Xuchang University,Xuchang Henan 461000,China) |
| Abstract: | Using sodium dodecyl sulfate(SDS)for the synergistic agent,placed at 20 minutes,based on the reaction of theophylline and cresol red,a simple,rapid and sensitive spectrophotometric method was described for the determination of theophylline,The complex has a maximum absorption at 570 nm,and its molar absorptivity is 5.56×105 L/(mol.cm),the method is high sensitivity and selectivity and Beer′s law is obeyed in the range of 0.10~8.00 μg/mL for theophylline with a determination limit of 0.172 μg/L(S/N=3,n=3).Line regression equation: A=0.064 36 C 0.058 50,correlation coefficient R=0.999 1. |
| Keywords: | theophylline sustained-release tablet theophylline cresol red spectrophotometry |
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