| 橙皮素芳酰腙化合物的微波合成与抑菌活性研究 |
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| 引用本文： | 刘万云,霍平,梅光泉,熊知行,王瑞君.橙皮素芳酰腙化合物的微波合成与抑菌活性研究[J].江西师范大学学报(自然科学版),2012,36(2):193-195. |
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| 作者姓名： | 刘万云 霍平 梅光泉 熊知行 王瑞君 |
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| 作者单位： | 1. 宜春学院江西省高等学校应用化学与化学生物学重点实验室,江西宜春336000;宜春学院江西省天然药物活性成分研究重点实验室,江西宜春336000
2. 宜春学院江西省高等学校应用化学与化学生物学重点实验室,江西宜春,336000 |
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| 基金项目： | 江西省教育厅科技课题(GJJ09638);江西省天然药物活性成分研究重点实验室开放课题资助项目 |
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| 摘 要： | 利用微波辐射技术,以橙皮素和芳酰肼为原料设计合成3种橙皮素芳酰腙类化合物,应用红外光谱、核磁共振谱、质谱和元素分析等分析手段对化合物进行了结构表征.抑菌活性实验表明,合成的3种橙皮素芳酰腙类化合物对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的抑菌活性与橙皮素相比均有较大增强.
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| 关 键 词： | 橙皮素 酰腙 微波合成 抑菌活性 |
The Study on Microwave Synthesis and Antibacterial Activity of Hesperetin Aromatic Hydrazone Compounds |
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| LIU Wan-yun
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HUO Ping
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MEI Guang-quan
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XIONG Zhi-xing
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WANG Rui-jun.The Study on Microwave Synthesis and Antibacterial Activity of Hesperetin Aromatic Hydrazone Compounds[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2012,36(2):193-195. |
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| Authors: | LIU Wan-yun HUO Ping MEI Guang-quan XIONG Zhi-xing WANG Rui-jun |
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| Institution: | 1(1.Key Laboratory of Jiangxi University for Applied Chemistry and Chemical Biology,Yichun University,Yichun Jiangxi 336000,China;2.Key Laboratory of Jiangxi Province for Research on Active Ingredients in Natural Medicines,Yichun University,Yichun Jiangxi 336000,China) |
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| Abstract: | Three hesperetin aromatic hydrazone compounds are synthesized in good yields under microwave irradiation by reaction of hesperetin with hydrazides.The structures of these compounds are confirmed by IR,1H NMR,MS spectra and elemental analysis.Inhibition test showed that the hesperetin aromatic hydrazone compounds against Escherichia coli,Staphylococcus aureus and Bacillus subtilis have good antibacterial activity,compared with hesperetin,have a greater enhancement of antibacterial activity. |
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| Keywords: | hesperetin hydrazone microwave synthesis antibacterial activity |
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