Inhibition of the growth of cariogenic bacteria in vitro by plant falvanones |
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| Authors: | H. Tsuchiya M. Sato M. Iinuma J. Yokoyama M. Ohyama T. Tanaka I. Takase I. Namikawa |
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| Affiliation: | (1) Department of Dental Pharmacology, Asahi University School of Dentistry, 1851 Hozumi, 501-02 Motosu (Gifu), Japan;(2) Department of Oral Microbiology, Asahi University School of Dentistry, Hozumi, 501-02 Motosu (Gifu), Japan;(3) Department of Pharmacognosy, Gifu Pharmaceutical University, 502 Mitahora (Gifu), Japan |
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| Abstract: | Phytoalexins, defensive compounds produced by plants against microbial infections, were purified fromSophora exigua (Leguminosae) and their growth inhibitory effects on oral cariogenic bacteria were determined in vitro. Among three isolated compounds, 5,7,2 ,4-tetrahydroxy-8-lavandulylflavanone completely inhibited the growth of oral bacteria including primary cariogenic mutans streptococci, other oral streptococci, actinomycetes, and lactobacilli, at concentrations of 1.56 to 6.25  g/ml. |
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| Keywords: | Antibacterial activity caries prevention cariogenic bacteria flavonoid growth inhibition phytoalexin |
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