| 滇黄精对大鼠脑缺血再灌注损伤神经元的作用 |
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| 引用本文： | 李微,彭锐,唐理斌,余俊才. 滇黄精对大鼠脑缺血再灌注损伤神经元的作用[J]. 大理学院学报：综合版, 2006, 5(10): 19-21 |
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| 作者姓名： | 李微 彭锐 唐理斌 余俊才 |
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| 作者单位： | 1. 大理学院2002级临床6班,云南,大理,671000
2. 大理学院2002级临床1班,云南,大理,671000 |
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| 摘 要： | 目的:探讨滇黄精对脑缺血/再灌注损伤的防治作用及其机理。方法:大鼠随机分为正常对照组、脑缺血/再灌注损伤模型组、滇黄精治疗组和复方丹参治疗组。夹闭双侧颈总动脉,建立脑缺血/再灌注损伤大鼠模型。测定血浆丙二醛(MDA)浓度、脑组织水含量,脑组织海马CA1区神经元记数。结果:滇黄精能减轻双侧颈总动脉结扎所致大鼠脑缺血/再灌注损伤的程度,降低大鼠血浆MDA的生成和血浆总钙含量,减轻脑水肿的程度;滇黄精治疗组海马CA1区正常神经元数目明显高于缺血组。结论:滇黄精可减轻全脑缺血/再灌注损伤,其机制与降低氧自由基水平有关。
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| 关 键 词： | 黄精 脑缺血/再灌注损伤 丙二醛 |
| 文章编号： | 1672-2345(2006)10-0019-03 |
| 收稿时间： | 2006-03-16 |
| 修稿时间： | 2006-03-16 |
The Effects and Mechanism of Polygonatum on Rat''''s Cerebral Ischemia Treatment |
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| LI Wei, PENG Rui, TANG Li-bin et al. The Effects and Mechanism of Polygonatum on Rat''''s Cerebral Ischemia Treatment[J]. Journal of Dali University, 2006, 5(10): 19-21 |
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| Authors: | LI Wei PENG Rui TANG Li-bin et al |
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| Affiliation: | College of Clinical Medicine, Dali University, Dali, Yunnan 671000, China |
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| Abstract: | Objective:To explore the protective effects of polygonatum and its mechanism during cerebral ischemia in rats.Methods: The rats are randomized into the control group,cerebral ischemia group,polygonatum-treated group and dan-shen root treated group.The malondialdehyde(MDA) in plasma is observed,water content of the brain tissue are also measured.Results: In cerebral ischemia group MDA content in plasma and water content of the brain tissues increase remarkably.In Polygonatum-treating group,the abnormal changes of indexes as above are improved markedly,and there is significant difference between IR group and Polygonatum group(P<0.05 and P<0.01),and normal neurons of hippocampus CA1 areas in Polygonatum-treating group are significantly higher than ischemia group in rats.Conclusion: Polygonatum can attenuate cerebral ischemia and its mechanism is related to its reducing oxygen free radicals. |
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| Keywords: | polygonatum cerebral ischemia malondialdehyde(MDA) |
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