Protein intrinsic disorder as a flexible armor and a weapon of HIV-1 |
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Authors: | Bin?Xue Marcin?J?Mizianty Lukasz?Kurgan Email author" target="_blank">Vladimir?N?UverskyEmail author |
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Institution: | (1) Department of Molecular Medicine, University of South Florida, College of Medicine, 12901 Bruce B. Downs Blvd, MDC07, Tampa, FL 33612, USA;(2) Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, T6G 2V4, Canada;(3) Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia; |
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Abstract: | Many proteins and protein regions are disordered in their native, biologically active states. These proteins/regions are abundant
in different organisms and carry out important biological functions that complement the functional repertoire of ordered proteins.
Viruses, with their highly compact genomes, small proteomes, and high adaptability for fast change in their biological and
physical environment utilize many of the advantages of intrinsic disorder. In fact, viral proteins are generally rich in intrinsic
disorder, and intrinsically disordered regions are commonly used by viruses to invade the host organisms, to hijack various
host systems, and to help viruses in accommodation to their hostile habitats and to manage their economic usage of genetic
material. In this review, we focus on the structural peculiarities of HIV-1 proteins, on the abundance of intrinsic disorder
in viral proteins, and on the role of intrinsic disorder in their functions. |
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