一种循环延长1,3,4-噁二唑-苯链的合成方法

1,3,4-噁二唑类化合物因具有独特的生物活性和光电性能而被广泛研究,在医药、有机电子和发光材料等领域具有广泛的应用价值.引入多个1,3,4-噁二唑结构单元,常常可以进一步提高此类化合物的功效性.通过将苯甲醛类化合物上的醛基转化为氰基后,再转化为四唑基,然后由苯四唑类化合物和对甲酰基苯甲酰氯反应生成1,3,4-噁二唑类化合物,此化合物保留了对甲酰基苯甲酰氯带入的醛基,可以进一步地采用相同方法循环反应下去,从而可以得到含有多个1,3,4-噁二唑-苯结构单元的系列链状化合物.

A synthetic method for extending the organic chain composed of cyclical 1,3,4-oxadiazole-benzene units

Due to particular bioactivities and photoelectric properties,organic compounds containing 1,3,4-oxadiazole have been widely investigated and applied in many fields,such as pharmaceutics,organic electronics and luminescent materials. The performances of these compounds usually would be improved by introducing multiple 1,3,4-oxadiazole groups. In this paper,a series of chain compounds composed of cyclical 1,3,4-oxadiazole-benzene units were synthesized through the aldehyde group on benzene ring being transformed successively into the cyano and 1H-tetrazole group,and then reacting with 4-formylbenzoyl chloride. Such reactions can be recycled continuously due to a new aldehyde group on benzene ring being introduced in the resultant compounds deriving from 4-formylbenzoyl chloride.