Induction of multi-epitopespecific antibodies against HIV-1 by multi-epitopevaccines |
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Authors: | Jian Ding Fei He Yun Lu Yi Xiao Yinghua Chen |
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Institution: | (1) Laboratory of Immunology, Research Center for Medical Science and Department of Biology, Tsinghua University Protein Science Laboratory of Ministry of Education of China, 100084 Beijing, China |
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Abstract: | Some neutralizing antibodies against HIV-1 envelope proteins were highly effective to inhibit the infection of different strainsin vitro, and existed in the infected individuals with very low levels. We suggested multi-epitope-vaccine as a new strategy to increase
levels of neutralizing antibodies and the abilities against HIV mutationin vivo. Two candidate multi-epitope-vaccines induced antibodies with predefined multi-epitope-specificity in rhesus macaque. These
antibodies recognized corresponding neutralizing epitopes on epitope-peptides, gp41 peptides, V3 loop peptide, rsgp41 and
rgp120. Besides, three candidate epitope-vaccines in combination (another kind of multi-epitopevaccines) showed similar potency
to induce predefined multiple immune responses in rabbits. These results suggest that multi-epitope-vaccines may be a new
strategy to induce multi-antiviral activities against HIV-1 infection and mutations. |
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Keywords: | HIV-1 multi-epitope-vaccine neutralizing epitope |
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