Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis |
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| Authors: | D Grunberger R Banerjee K Eisinger E M Oltz L Efros M Caldwell V Estevez K Nakanishi |
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| Institution: | (1) Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 10032 New York, New York, USA;(2) Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, 10032 New York, New York, USA;(3) Department of Biological Sciences, Columbia University, 10027 New York, New York, USA;(4) Department of Chemistry, Columbia University, 10027 New York, New York, USA |
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| Abstract: | Summary The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE. |
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| Keywords: | Honebee hive propolis caffeic acid ester cytoxicity |
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