Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion |
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| Authors: | M J Zigmond E M Stricker |
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| Institution: | (1) Departments of Biological Sciences and Psychology, University of Pittsburgh, 15260 Pittsburgh, PA, USA;(2) the Neuropsychobiology Program, University of Pittsburgh, 15260 Pittsburgh, PA, USA |
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| Abstract: | Summary 6-Hydroxydopamine increased behavioral response to L-DOPA in proportion to the decrease of dopamine (DA) and DA uptake in rat striatum. The increased response to apomorphine, however, only occurred after >80% DA loss. Thus, 6-hydroxydopamine may induce postsynaptic changes only following large lesions.Supported in part by USPHS grants No. MH-00058 and MH-20620. We thank Kathleen Hays, Suzanne Wuerthele and Dennis McKeag for technical assistance. |
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