多菇口服液毒理安全性实验研究

目的检测多菇口服液作为保健食品的安全性。方法通过小鼠经口急性毒性试验、致突变试验,大鼠30d喂养试验对多菇口服液进行检测。结果小鼠经口LD50>21.5g/kg,属无毒级物质;致突变试验结果为阴性;大鼠30d喂养试验表明各剂量组体重增长、食物利用率、脏体比、血液学及血清生化指标与对照组比较均无显着性差异(P>0.05)。病理检查主要脏器未发现与实验有关的病理性改变。结论多菇口服液为无毒、无致突变作用的保健食品。

An Exprimental Study on The Toxicity Safety DUOGU Oral Liquid

Objective Evaluate the security of Duogu oral liquid as heaith food. Methods According to ministry of Pubic Health（（The technical standards for testing and assessment of health food》, to test the Duogu oral liquid by the acute toxicity test with oral administration on mice and mutagenicity test and thirty days feed tese on rats. Results Semi-lethal dose of mice with oral administration was more than 21.5 g/kg, The result indicated that the Duogu oral liquid has no toxicity. Thethirty days feeding test of rats indicated that the body weight was increasing; there were no significant difference of food exploit rate, organ/weight ratio, hematology and serum biochemical guideline quota of every dosage group compared with the control group（p 〈 0.05）. The pathological change related to experiment was not found by pathological examination. Conclusion Duogu oral liquid is a health food without toxicity and mutagenicity.