| Synchrotron refractive-index microradiography of human liver cancer tissue |
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| 作者姓名： | TONG Yongpeng ZHANG Guilin LI Yan HWU Yeukuang TSAI Wenli JE Jung Ho Margaritondo G YUAN Dong |
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| 作者单位： | [1]Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China [2]Institute of Physics Academia Sinica Nankang Taipei, China [3]Department of Material Science and Engineering, Pohang Universty of Science and Technology Pohang, Korea [4]IPA-Ecole Polytechnique Federale de Lausanne （EPFL）, CH-1015 Lausanne, Switzerland [5]Shanghai CDC, Shanghai 200336, China |
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| 基金项目： | Acknowledgements This work was supported by the Major Project of National Natural Science Foundation of China （Grant No. 10490182）, the Major Project of Knowledge Innovation Program of Chinese Academy of Sciences （KJCX2-SW-No 1）, Science Council of Taiwan, the P0STECH research fund （1RB9907801） and the Swiss Founds National pour la Recherche Scientifique and the EPFL. |
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| 摘 要： | Three human liver tissue samples （-5 mm × 40 mm × 20 mm） were excised from a cancer patient＇s liver during surgery. The microradiology analysis was performed with a non-standard approach on a synchrotron. High-resolution refractive-index edge-enhanced microradiographs that cover a larger volume of the liver tissue sample were obtained. The cancer tissue and normal tissue could be clearly identified and distinguished based on their different textures. Furthermore, new blood vessel hyperplasia was found near the cancer area. Blood vessels with a diameter smaller than 20 μm could be identified. These findings were fully consistent with the histopathological examination or the same area. Microradiographs of the newly formed blood vessels at different angles were also obtained. This result shows that it is possible to further develop this approach into a technique of microradiographic imaging for clinic diagnosis of liver cancer at the early stage.
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| 关 键 词： | 肝癌 同步加速器 折射系数 X射线显微照相术 组织病理学 |
| 收稿时间： | 2005-04-18 |
| 修稿时间： | 2005-04-182005-07-26 |
Synchrotron refractive-index microradiography of human liver cancer tissue |
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| TONG Yongpeng ZHANG Guilin LI Yan HWU Yeukuang TSAI Wenli JE Jung Ho Margaritondo G YUAN Dong.Synchrotron refractive-index microradiography of human liver cancer tissue[J].Chinese Science Bulletin,2005,50(22):2657-2661. |
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| Authors: | Yongpeng Tong Guilin Zhang Yan Li Yeukuang Hwu Wenli Tsai Jung Ho Je G Margaritondo Dong Yuan |
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| Abstract: | Three human liver tissue samples (～5 mm × 40 mm × 20 mm) were excised from a cancer patient’s liver during surgery. The microradiology
analysis was performed with a non-standard approach on a synchrotron. High-resolution refractive-index edge-enhanced microradiographs
that cover a larger volume of the liver tissue sample were obtained. The cancer tissue and normal tissue could be clearly
identified and distinguished based on their different textures. Furthermore, new blood vessel hyperplasia was found near the
cancer area. Blood vessels with a diameter smaller than 20 μm could be identified. These findings were fully consistent with
the histopathological examination of the same area. Microradiographs of the newly formed blood vessels at different angles
were also obtained. This result shows that it is possible to further develop this approach into a technique of microradiographic
imaging for clinic diagnosis of liver cancer at the early stage. |
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| Keywords: | synchrotron microradiology liver cancer histopathology |
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