Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13 |
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| Authors: | Barton Anne,Thomson Wendy,Ke Xiayi,Eyre Steve,Hinks Anne,Bowes John,Plant Darren,Gibbons Laura J Wellcome Trust Case Control Consortium YEAR Consortium BIRAC Consortium,Wilson Anthony G,Bax Deborah E,Morgan Ann W,Emery Paul,Steer Sophia,Hocking Lynne,Reid David M,Wordsworth Paul,Harrison Pille,Worthington Jane |
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| Affiliation: | Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK. anne.barton@manchester.ac.uk |
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| Abstract: | ![]()
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry. |
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