MYH9 is associated with nondiabetic end-stage renal disease in African Americans |
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| Authors: | Kao W H Linda,Klag Michael J,Meoni Lucy A,Reich David,Berthier-Schaad Yvette,Li Man,Coresh Josef,Patterson Nick,Tandon Arti,Powe Neil R,Fink Nancy E,Sadler John H,Weir Matthew R,Abboud Hanna E,Adler Sharon G,Divers Jasmin,Iyengar Sudha K,Freedman Barry I,Kimmel Paul L,Knowler William C,Kohn Orly F,Kramp Kristopher,Leehey David J,Nicholas Susanne B,Pahl Madeleine V,Schelling Jeffrey R,Sedor John R,Thornley-Brown Denyse,Winkler Cheryl A,Smith Michael W,Parekh Rulan S Family Investigation of Nephropathy Diabetes Research Group |
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| Affiliation: | Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA. wkao@jhsph.edu |
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| Abstract: | As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans. |
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