| 4—甲基—6—羟基—2—吡啶酮衍生物的互变异构研究 |
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| 引用本文： | 刘辉,王璧人,等.4—甲基—6—羟基—2—吡啶酮衍生物的互变异构研究[J].大连理工大学学报,1992,32(4):405-411. |
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| 作者姓名： | 刘辉 王璧人 |
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| 作者单位： | 大连理工大学化工学院
(刘辉，王璧人，李慕洁)，大连理工大学化工学院(彭勤纪) |
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| 摘 要： | 合成和精制了五个４－甲基－６－羟基－２－吡啶酮衍生物，用核磁共振波谱和 红外光谱研究了它们在氘代二甲基亚砜溶液中的烯醇式、双酮式互变异构平 衡。热力学参数的计算表明，从烯醇式到双酮式构型的转变是一个吸热过程。 当氮原子上带有体积较大的取代基时，在相同的条件下，化合物更容易以双 酮式构型存在。
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| 关 键 词： | 互变异构 光变分析 吡啶酮衍生物 |
Investigation of tautomerism of 4-methyl-6-hydroxy-2-pyridone derivatives |
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| Liu Hui,Wang Biren,Li Mujie,Peng Qinji.Investigation of tautomerism of 4-methyl-6-hydroxy-2-pyridone derivatives[J].Journal of Dalian University of Technology,1992,32(4):405-411. |
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| Authors: | Liu Hui Wang Biren Li Mujie Peng Qinji |
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| Abstract: | Five 4-methyl-6-hydroxy-2-pyridone derivatives are synthesized and purified. Their enol- keto tautomeric equilibria in solution of deuterium dimethyl sulfoxide are investigated by NMR and Infrared spectra. The calculation of the thermodynamic parameters shows that the transfor- mation from enol to keto form is endothermic process. The compounds with bulky substituents on N-atom preferably exist in keto form on the same condition of determination. |
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| Keywords: | spectrographic analysis NMR spectrometry infrared spectrophotometry tautomerism / 4-methyl- 6 - hydroxy- 2 - pyridone derivatives |
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