Role of hepcidin in murine brain iron metabolism |
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| Authors: | S-M Wang L-J Fu X-L Duan D R Crooks P Yu Z-M Qian X-J Di J Li T A Rouault Y-Z Chang |
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| Institution: | (1) Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, 050016 Shijiazhuang, Hebei, People’s Republic of China;(2) Molecular Medicine Program, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA;(3) Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Jiulong, Hong Kong |
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| Abstract: | Brain iron homeostasis is maintained by a balance of both iron uptake and release, and accumulating evidence has revealed
that brain iron concentrations increase with aging. Hepcidin, an iron regulatory hormone produced by hepatocytes in response
to inflammatory stimuli, iron, and hypoxia, has been shown to be the long-sought hormone responsible for the regulation of
body iron balance and recycling in mammals. In this study, we report that hepcidin is widely expressed in the murine brain.
In cerebral cortex, hippocampus and striatum, hepcidin mRNA levels increased with aging. Injection of hepcidin into the lateral
cerebral ventricle resulted in decreased Fpn1 protein levels in cerebral cortex, hippocampus, and striatum. Additionally,
treatment of primary cultured neurons with hepcidin caused decreased neuronal iron release and Fpn1 protein levels. Together,
our data provide further evidence that hepcidin may be involved in the regulation of brain iron metabolism. |
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