基于Geant4的硼中子俘获治疗的能量沉积分布研究

硼中子俘获治疗(BNCT)是一种治疗癌症的有效手段。采用国际通用的Geant4开发程序包,以Snyder模型为对象,构建中子输运计算模型,评估在给定中子束流能谱和入射方向条件下,脑组织吸收不同¹⁰B质量比的含硼药物对癌变组织及正常组织的能量沉积的来源和分布情况。研究表明,¹⁰B引起的能量沉积呈先升高后降低的变化趋势,在入射深度为3.0 cm处达到峰值;在入射深度为2~5 cm区间内,能量沉积主要来自¹⁰B;¹⁰B引起的能量沉积与¹⁰B质量比呈线性关系;光子、质子、电子及其他粒子引起的能量沉积占比很小,且不随¹⁰B质量比的变化而变化。研究结果对BNCT的方案设计、效果评估具有参考意义。

Study on Energy Deposition Distribution of Boron Neutron Capture Therapy Based on Geant4

Boron neutron capture therapy (BNCT) is an effective method for the treatment of cancer. The Snyder model is taken as the object to construct the calculation model of neutron transport by using the international Geant4 development package. The source and distribution of energy deposition in canceration tissues and normal tissues absorbed by different concentrations of boron-containing drugs in brain tissue is evaluated under the conditions of given neutron beam energy spectrum and incident direction. The results show that,the energy deposition caused by boron-10 increases at first and then decreases,and reaches the peak at the incident depth of 3.0 cm,and the energy deposition mainly comes from boron-10 when the incident depth is 2.0~5.0 cm. The energy deposition caused by boron-10 is linearly related to the concentration of boron-10,and the proportion of energy deposition caused by photons,protons,electrons and other particles is very small and does not change with the concentration of boron-10. The research results have reference significance for the scheme design and effect evaluation of BNCT.