| 无溶剂合成2-氨基噻唑和2-甲基噻唑衍生物 |
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| 引用本文： | 王书香,武倩倩,段杰,郭少波.无溶剂合成2-氨基噻唑和2-甲基噻唑衍生物[J].河北大学学报(自然科学版),2010,30(1). |
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| 作者姓名： | 王书香 武倩倩 段杰 郭少波 |
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| 作者单位： | 河北大学,化学与环境科学学院,河北省化学生物学重点实验室,河北,保定,071002 |
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| 基金项目： | 河北大学自然科学基金资助项目(2007-087) |
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| 摘 要： | 在无溶剂和催化剂的条件下,以卤代酮和硫脲或取代硫脲为原料,于100℃反应5～15 min,合成了2-氨基噻唑及2-甲基噻唑类衍生物.在明显减少硫脲或取代硫脲用量的基础上,使产物的收率达到了85%～98%.此方法具有反应条件温和、操作简单、反应时间短和收率高等特点.
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| 关 键 词： | 无溶剂 无催化剂 2-氨基噻唑 2-甲基噻唑 |
Solvent-free Synthesis of 2-Aminothiazoles and 2-Methylthiazoles |
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| WANG Shu-xiang,WU Qian-qian,DUAN Jie,GUO Shao-bo.Solvent-free Synthesis of 2-Aminothiazoles and 2-Methylthiazoles[J].Journal of Hebei University (Natural Science Edition),2010,30(1). |
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| Authors: | WANG Shu-xiang WU Qian-qian DUAN Jie GUO Shao-bo |
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| Institution: | Key Laboratory of Chemical Biology of Hebei Province;College of Chemistry and Environmental Science;Hebei University;Baoding 071002;China |
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| Abstract: | A series of 2-aminothiazoles, 2-methylthiazoles were synthesized by the reaction of phenacyl halides, thioura or thioacetamide under solvent-free and catalyst-free conditions. The reactions were completed within 5-15 min giving the yields of 85%-98%, and the amount of thioura or thioacetamide was reduced to equivalent mole. The procedure offers several advantages including milder reaction conditions, easier work-up, shorter reaction time, and higher yields. |
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| Keywords: | solvent-free catalyst-free 2-aminothiazoles 2-methylthiazoles |
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