Molecular mechanism of abnormal aggresation of α-synuclein |
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作者姓名: | HU HongYu LIN Xiaoding |
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作者单位: | State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 200031, China |
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基金项目: | We are grateful to all the researchers and graduates who participated in the current study. |
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摘 要: | The abnormal aggregation of α-synuclein (α-Syn) is thought to be closely associated with Parkinson's disease, but the pathogenesis is still unclear. In this review, we survey the latest development in the molecular mechanism of abnormal α-Syn aggregation, especially in the aspects of the core sequences, aggregation inhibitors, structural transformation and filament morphologies. By exploring the mechanism of α-Syn aggregation, we will have a better understanding of the disease pathogenesis, and develop strategies for preventing and treating this severe disease.
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关 键 词: | 帕金森综合征 分子机制 发病机理 聚集 |
收稿时间: | 24 July 2006 |
修稿时间: | 2006-07-242006-11-14 |
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