乳腺癌中CyclinB1表达及临床病理意义

目的:研究细胞周期蛋白B1、癌基因C-erbB-2和雌激素受体(ER)、孕激素受体(PR)在乳腺癌中的表达情况及临床意义.方法:采用S-P免疫组化方法对65例乳腺癌组织和15例乳腺纤维瘤组织进行cy-clinB1、C-erbB-2和ER、PR表达的联合检测.结果:乳腺癌组织中CyclinB1过阳性表达率为84.62%(55/65);乳腺纤维瘤组织CyclinB1表达率为13.3%(2/15);淋巴结转移患者CyclinB1蛋白的过阳性表达率明显高于淋巴结阴性患者;CyclinB1的表达与C-erbB-2表达具有相对的一致性,CyclinB1的阳性高表达伴随ER表达降低,但与PR的表达无显著相关性.结论:CyclinB1的过表达与乳腺癌的发生、发展相关,过表达cy-clinB1可为乳腺癌早期诊断和生物学行为的判断提供帮助.CyclinB1与C-erbB-2和ER、PR的联合检测有利于指导乳腺癌的化疗和判断预后.

Expression of CyclinB1 in Breast Cancer and Its Clinicopathologic Significance

Objective:To study the expression of cyclinB1,C-erbB-2,ER and PR in breast cancer and to evaluate their clinical significance.Methods: Immunohistochemical method was used to analyze the expression of cyclinB1,C-erbB-2,ER and PR in breast cancer.Results: Positive rate of overexpression of cyclinB1 in breast cancer was 86.24%,in fibroadenoma of breast the expression rate was 13.3%,statistically significant difference was found between two groups.The expression of cyclinB1 was significantly increased in breast cancer with metastasis compared with that without metastasis.High co-expression of cyclinB1 and C-erbB-2 was found in tumor cells.The expression of ER was decreased in the patients with high expression of cyclinB1,and there was no relationship between the expression of cyclinB1 and PR.Conclusion: Overexpression of cyclinB1 is involved in carcinogenesis and development of breast cancer,and the detection of correlative expression of cyclinB1,ER,PR and C-erbB-2 may have advantages for the choice of therapeutic scheme.