Influence of dopamine infusion on plasma prolactin released by kidney capsule transplanted anterior pituitaries

Summary The infusion of dopamine into the renal artery resulted in decreased prolactin release from 3 anterior pituitary glands transplanted under the kidney capsule. Prolactin levels continually decreased over a 5 min period after DA infusion was terminated and thereafter approached preinfusion levels by the end of 10 min.Supported by NSF Research, grant No. 74-17332.The authors wish to express their appreciation to Mrs Cynthia Van De Walle for her outstanding technical assistance in the performance of the prolactin RIA and the statistical analyses. We also appreciate receiving as a gift from the National Institute for Arthritis, Metabolism and Digestive Diseases the rat prolactin used for iodination (RP-I₂) and standards (RP-1).