| 亚乙基-1,2-双氨基二硫代甲酸苄酯化合物的合成及生物活性研究 |
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| 引用本文： | 刘志昌,唐琼,黄明远,张贇.亚乙基-1,2-双氨基二硫代甲酸苄酯化合物的合成及生物活性研究[J].四川师范大学学报(自然科学版),2007,30(4):500-502. |
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| 作者姓名： | 刘志昌 唐琼 黄明远 张贇 |
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| 作者单位： | 乐山师范学院,化学与生命科学系,四川,乐山,614004 |
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| 基金项目： | 四川省青年基金;四川省教育厅自然科学基金 |
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| 摘 要： | 在无水磷酸钾存在下,以丙酮为溶剂,乙二胺和二硫化碳反应后再分别与苄溴、2-氯苄氯、4-氯苄氯、2,4-二氯苄氯在室温下反应,以较好收率合成了亚乙基-1,2-双氨基二硫代甲酸取代苄酯（4a-d）,其结构通过1H NMR、IR、MS和元素分析表征;初步生物活性实验结果表明化合物（4a-d）有较好的抑菌作用.
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| 关 键 词： | 氨基二硫代甲酸苄酯 生物活性 合成 |
| 文章编号： | 1001-8395（2007）04-0500-03 |
| 收稿时间： | 2006-03-08 |
| 修稿时间： | 2006-03-08 |
Synthesis and Biological Activity of Enthylene-1,2-Diamino Benzyl Dithiocarbamates |
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| LIU Zhi-chang,TANG Qiong,HUANG Ming-yuan,ZHANG Yun.Synthesis and Biological Activity of Enthylene-1,2-Diamino Benzyl Dithiocarbamates[J].Journal of Sichuan Normal University(Natural Science),2007,30(4):500-502. |
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| Authors: | LIU Zhi-chang TANG Qiong HUANG Ming-yuan ZHANG Yun |
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| Abstract: | Ethylidene-1,2-diamino benzyl dithiocarbamates were synthesized by the reaction of ethyldiamine with carbon disulfide,and then with a variety of alkyl halides such as Benzyl bromide,2-chlorobenzyl chloride,2,4-Dichlorobenzyl chloride or 4-chlorobenzyl chloride,respectively,at room temperature and in the presence of anhydrous potassium phosphate.All the prepared compounds were characterized by 1HNMR,IR,MS and elemental analysis.It is shown,by the experimentation of biological activity,that some of the compounds(4a-d) have the performance of obvious inhibiting of microbe. |
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| Keywords: | Dithiocarbamate Biologcal activities Synthesis |
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