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Proopiomelanocortin expression in the skin during induced hair growth in mice |
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| Authors: | A Slominski R Paus J Mazurkiewicz |
| Institution: | (1) Department of Immunology and Microbiology, Albany Medical College, 12202 Albany, New York, USA;(2) Department of Anatomy, Cell Biology and Neurobiology, Albany Medical College, 12202 Albany, New York, USA;(3) Department of Dermatology, University Hospital R. Virchow, Freie Universität Berlin, D-1 Berlin 65, (Germany) |
| Abstract: | We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti  -endorphin in late but not early anagen or telogen skin. By immunocytochemistry, -endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner. |
| Keywords: | Proopiomelanocortin hair growth skin C57B1/6 mice |
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