羰基铁粉介导的动脉栓塞热疗的可行性研究

 为评价羰基铁粉作为动脉栓塞热疗的一种新型介质的可行性，通过进行羰基铁粉形态学观察和粒径分布检测，对其理化性质进行初步表征；利用L929成纤维细胞进行体外细胞实验，并进行大鼠体内毒性实验，检查羰基铁粉的细胞毒性和生物相容性；体外升温实验中，将羰基铁粉和碘油的混悬液暴露于外界交变磁场，通过设置不同的羰基铁粉含量和磁场强度，评价羰基铁粉在外界交变磁场下的升温情况；体内实验中，以正常新西兰大耳白兔作为动物模型，对其肝动脉进行经动脉栓塞热疗，对比热疗过程中肝组织温度和体温变化情况，并对热疗后兔肝进行病理学检查。细胞毒性研究表明，羰基铁粉具有良好的生物相容性；体内和体外的升温情况表明，在外界交变磁场作用下，羰基铁粉具有理想的升温特性。由此说明，对于动脉栓塞热疗来说，羰基铁粉是一种极具潜力的临床应用候选介质。

Feasibility Study of Carbonyl Iron Powder as a Novel Mediator of Arterial Embolization Hyperthermia for Liver Cancer Treatment

This paper explores the feasibility of carbonyl iron powder to be used as a novel mediator of arterial embolization hyperthermia. Based on in vitro morphology study, the particle diameter distribution of the carbonyl iron powder is measured by laser light scattering with particle size analyzer, and the morphology of these particles is observed by Scanning Electron Microscopy(SEM). Mouse fibroblast L-929 cells are cultured in the medium of extraction of carbonyl iron powder. The cytotoxicity is graded by the generally accepted standard. In in vitro heating experiment, different doses of carbonyl iron powder/Lipiodol suspension are heated in an alternating magnetic field. The influences of the doses of suspension and the magnetic field are observed. As animal models, the normal New Zealand half lop rabbits are treated with arterial embolization hyperthermia by using the suspension. Cytotoxicity study demonstrates that Carbonyl Iron Powder (CIP) shows good biocompatibility. The heating profiles of in vitro and in vivo experiments reveal that CIP possesses the ideal property with inductive heating characteristics under the alternative magnetic field and it does not affect the normal temperature of animal models. These findings suggest that CIP is a very promising mediator candidate of arterial embolization hyperthermia for clinical applications.