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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer |
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| Authors: | Stephens Philip Edkins Sarah Davies Helen Greenman Chris Cox Charles Hunter Chris Bignell Graham Teague Jon Smith Raffaella Stevens Claire O'Meara Sarah Parker Adrian Tarpey Patrick Avis Tim Barthorpe Andy Brackenbury Lisa Buck Gemma Butler Adam Clements Jody Cole Jennifer Dicks Ed Edwards Ken Forbes Simon Gorton Matthew Gray Kristian Halliday Kelly Harrison Rachel Hills Katy Hinton Jonathon Jones David Kosmidou Vivienne Laman Ross Lugg Richard Menzies Andrew Perry Janet Petty Robert Raine Keiran Shepherd Rebecca Small Alexandra Solomon Helen Stephens Yvonne Tofts Calli Varian Jennifer |
| Affiliation: | The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. |
| Abstract: | We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure. |
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